BLOG 495 CUSHING'S SYNDROME
High
levels of cortisol are a tell-take sign of the condition called Cushing’s syndrome.
Another term for this is “hypercortisolism”. Dr. Cushing is credited for his
research and discovery of this illness in 1912. Cortisol isn’t an all-bad
hormone. We do need it for stress response, converting macronutrients into
energy, balancing insulin, regulating blood pressure, and reducing
inflammation. However, when the body produces too much cortisol there are
adverse health effects. Too much stress, excessive alcohol use, malnutrition,
depression, panicking, and over training, can all lead to more cortisol
production than normal.
There can
be several symptoms of Cushing’s syndrome. Some signs include thin skin that
bruises easily, purple stretch marks on the body, fatty deposits in mid-section
and upper back, round moon shaped face, weight gain, skin injuries that don’t
heal normal timing, acne, muscle weakness, and feeling fatigue. There are other
commonalities among people who have Cushing’s. These can include feeling
thirsty often, frequent urination, mood changes, high blood pressure,
headaches, anxiety, irritability, and irregular menstruation.
Cushing’s
syndrome is more common in females than males. Females will develop more body
hair around the face and neck, thighs, chest, and abs. Irregular menstruation
is common with possibly no menstruation at all. Males might experience erectile
dysfunction and loss of interest in sex.
One of the
leading causes of developing Cushing’s syndrome is the prolonged use of corticosteroids.
Prednisone taking in high amounts for extended periods of time and injections
for back pain are common culprits. Diagnosis is complicated. Cortisol levels
can be tested via a urinary test, saliva test, ruling out the causes of high
cortisol with Dexamethasone-CRH test (such as alcoholism), or taking a low dose
of dexamethasone which lowers cortisol (but if it doesn’t than it would be
Cushing’s syndrome). After Cushing’s syndrome is determined to be the
cause of high cortisol, a doctor would then want to test what has caused the
high cortisol levels in the first place. Testing for a tumor on the adrenal
glands is critical.
There are
medications which can help lower the production of cortisol. These include Nizoral,
Korlym, Mifeprex, Lysodren, and Signifor. Lifestyle changes can also help avoid
Cushing syndrome and suppress symptoms. Weight loss, low sodium diet, no
alcohol, managing blood sugar, and making sure levels of vitamin C and D are
sufficient are important. In a go, go, go world, stress is inevitable but
making sure it is not prolonged, and constant is critical. Hormones wreak havoc
when left to their own control of our body. Being proactive which is involves being active and leading a
healthy lifestyle, is the best measure we can take for our overall health.